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Diabetic ketoacidosis (DKA) is a dangerous complication of diabetes caused by a lack of insulin in the body.
Diabetic ketoacidosis occurs when the body is unable to use blood sugar (glucose) because there isn't enough insulin. Instead, it breaks down fat as an alternative source of fuel. This causes a build-up of a by-product called ketones.
Symptoms of diabetic ketoacidosis include:
Seek immediate medical assistance if you have any of these symptoms and your blood sugar levels are high.
Read more about the symptoms of diabetic ketoacidosis.
Diabetic ketoacidosis is a relatively common complication in people with diabetes, particularly children and younger adults who have type 1 diabetes.
Younger children under four years of age are thought to be most at risk.
In about 1 in 4 cases, diabetic ketoacidosis develops in people who were previously unaware they had type 1 diabetes.
Diabetic ketoacidosis accounts for around half of all diabetes-related hospital admissions in people with type 1 diabetes.
Read more about potential causes of diabetic ketoacidosis.
This is a relatively straightforward process.
Blood tests can be used to check your glucose levels and any chemical imbalances, such as low levels of potassium. Urine tests can be used to estimate the number of ketones in your body.
Blood and urine tests can also be used to check for an underlying infection, which could be a trigger.
After diabetic ketoacidosis has been diagnosed, you'll probably need regular blood and urine tests to check how well you're responding to treatment.
If the condition is diagnosed very early, it may be possible to relieve the symptoms with an insulin injection.
People with more advanced diabetic ketoacidosis will need to be admitted to hospital where they will be given a combination of insulin and fluids.
Read more about treating diabetic ketoacidosis.
If you have type 1 diabetes, it's important you follow your recommended treatment plan, both in terms of taking regular insulin injections as directed and monitoring your blood glucose levels, particularly if you feel unwell.
Read more about preventing diabetic ketoacidosis.
Diabetic ketoacidosis is potentially very serious. High levels of ketones in the blood disrupt normal working of many parts of the body. The more ketones in the blood, the more ill a person with diabetic ketoacidosis will become.
Read more about the complications of diabetic ketoacidosis.
The initial symptoms of diabetic ketoacidosis (DKA) develop when the body detects that ketones are being produced.
High blood glucose and ketone levels make you pass large amounts of urine. This will make you very thirsty and can lead to dehydration.
Ketones are acidic so as more are produced, the level of acid in your blood will rise. The combination of dehydration and high blood acid levels can trigger a range of additional symptoms such as:
Left untreated, more advanced symptoms will develop such as:
If you think you're experiencing the initial symptoms of diabetic ketoacidosis, and self-testing shows high levels of ketones in your blood or urine, you should immediately contact your doctor or diabetes nurse for advice.
If you, or someone in your care, appears to be experiencing more advanced symptoms of diabetic ketoacidosis, go immediately to your nearest accident and emergency (A&E) department.
Diabetic ketoacidosis (DKA) is a complication of diabetes that can occur if the body starts to run out of insulin (the hormone that regulates blood sugar).
It can be caused by a number of underlying problems including an infection, a missed insulin injection or undiagnosed diabetes (see below). In some cases, it may also be triggered by another illness, such as a stroke or a heart attack.
A lack of insulin can send the body’s metabolism into a destructive downward spiral. The metabolism is the complex process of chemical reactions the body uses to break down food into energy.
Insulin enables the body to use blood sugar (glucose). If there is a lack of insulin, or if it can't be used properly, the body will break down fat instead.
The breakdown of fat releases acidic chemicals (ketones). High levels of glucose and ketones make you pass large amounts of urine. This can lead to severe dehydration.
Therefore, there are a number of interlinked problems with the body’s metabolism that can quickly make a person very ill. These are:
The three most common triggers for diabetic ketoacidosis are:
These are discussed in more detail below.
The body’s response to infection is to produce more glucose. Too much glucose can make insulin treatment ineffective, triggering diabetic ketoacidosis.
The most common infections are:
There are a number of reasons why someone with diabetes may miss their recommended treatment including:
The symptoms of type 1 diabetes often develop quickly, and a delay in diagnosing the condition can sometimes progress to diabetic ketoacidosis.
However, this only occurs in a small number of people with type 1 diabetes which suggests they have a particularly severe form of the condition compared to other people.
Less common triggers for diabetic ketoacidosis include:
Diabetic ketoacidosis (DKA) is usually treated in hospital.
Depending on how advanced your symptoms are you may be admitted to a standard ward, a high dependency ward or an intensive care unit (ICU).
Diabetic ketoacidosis is treated using a combination of:
If someone with diabetic ketoacidosis is unconscious, a feeding tube can be used to remove stomach contents and stop them breathing in vomit. Urine can be drained out of the bladder using a thin tube called a catheter.
As long as there are no complications, you should be able to leave hospital when you are well enough to eat and drink normally and tests show no, or few, ketones left in your body.
Before or shortly after being discharged from hospital, your diabetes nurse will discuss why you had an episode of diabetic ketoacidosis so a plan can be put in place to prevent future episodes.
For example, if diabetic ketoacidosis was caused by an illness, you'll need a 'sick day plan' so you can adjust your insulin dosage accordingly.
If diabetic ketoacidosis occurred as a result of missing an insulin treatment, you'll need to discuss the reasons for this and whether there's anything that can be done to make insulin therapy more convenient.
If you've been diagnosed with diabetes, it's very important that you follow all recommendations regarding diet, medication, insulin therapy and self-testing.
An underlying illness (usually an infection) is the most common reason why people with type 1 diabetes develop diabetic ketoacidosis (DKA). It's therefore important to take extra precautions if you fall ill.
You can use the advice below as a guide.
It's likely you will have to increase your insulin injections when you are ill. You should have received previous instructions about this, known as your 'sick day rules'. Contact your doctor or diabetic nurse for advice if you haven't received these instructions.
You will also need to check your blood glucose levels more frequently (usually at least four times a day).
A simple urine test, using strips available on prescription, can test for ketones. You should test your urine for ketones if you have a high blood sugar level or if you have the symptoms of ketoacidosis.
Many newer blood glucose monitors are also able to monitor blood ketone levels. Your diabetic nurse will be able to provide you with more information about this.
Contact your doctor or diabetes nurse immediately, or go to your nearest accident and emergency department, if you have a blood sugar level and the test strips indicate that you also have high levels of ketones.
With prompt treatment, complications of diabetic ketoacidosis (DKA) are uncommon.
However, when complications do occur they are usually serious. The complications of diabetic ketoacidosis are described below.
Swelling of the brain is a very serious complication of diabetic ketoacidosis. It's caused when excess water builds up inside the brain. The medical term for this is cerebral oedema.
Cerebral oedema is usually seen in children and it occurs in around 1 in every 150 cases of diabetic ketoacidosis. It's not known why water builds up in the brain in this way.
Symptoms of cerebral oedema include:
Cerebral oedema is very serious and can cause severe brain damage. In around 1 in 4 cases this can be fatal.
A person with cerebral oedema will be admitted to an intensive care unit (ICU) and treated with a medication called mannitol, which helps reduce the brain swelling.
Your kidneys remove waste products from your blood, so if they stop working you may experience a range of symptoms such as:
Until your dehydration has been successfully treated, you may need dialysis. This is a treatment that uses a machine to filter waste products from your blood.
Once your fluid levels have been restored to normal, your kidneys should start to recover.
The rapid and unpredictable changes in fluid levels that can occur in diabetic ketoacidosis can occasionally result in the lungs becoming filled with fluid. This is known as adult respiratory distress syndrome and can cause serious breathing difficulties.
If you develop adult respiratory distress syndrome, a machine called a ventilator can be used to help you breathe until your condition stabilises.
Important: Our website provides useful information but is not a substitute for medical advice. You should always seek the advice of your doctor when making decisions about your health.