Sepsis is a life-threatening illness caused by the body overreacting to an infection.
The body’s immune system goes into overdrive, setting off a series of reactions that can lead to widespread inflammation (swelling) and blood clotting.
Symptoms usually develop quickly and include:
In severe cases you may notice:
Read more about the symptoms of sepsis.
Although anybody can develop sepsis from a minor infection, some people are more vulnerable, such as those:
Read more information about the causes of sepsis.
Sepsis develops in three stages, described below.
If it is not treated, sepsis can progress from uncomplicated sepsis to septic shock and can eventually lead to multiple organ failure and death.
If you think you have sepsis, it is important to get it diagnosed and treated as quickly as possible.
If you think that you or someone in your care has severe sepsis or septic shock, phone for an ambulance.
Read more information about how sepsis is diagnosed.
If sepsis is detected early and has not yet affected vital organs, it may be possible to treat the infection at home with antibiotics. Most people with uncomplicated sepsis make a full recovery.
Severe sepsis and septic shock are considered medical emergencies and normally require admission to an intensive care unit, where the body’s organs can be supported while the infection is treated.
Because of problems with vital organs, people with severe sepsis are likely to be very ill, and approximately 30-50% will die as a result of the condition.
Read more information about how sepsis is treated.
It is estimated that there are over 30,000 cases of severe sepsis in the UK every year, and the number seems to be rising.
The symptoms of sepsis may develop after a localised infection (infection limited to one part of the body) or an injury.
In some cases, sepsis may develop when you are already in hospital, for example if you have recently had surgery and a drip or catheter has been connected to your body. Read more about the causes of sepsis.
The symptoms of sepsis usually develop quickly and include:
Symptoms of severe sepsis or septic shock include:
The most common sites of infection leading to sepsis are the lungs, urinary tract, abdomen and pelvis.
Severe sepsis and septic shock are medical emergencies. If you think that you or someone in your care has these conditions speask to an emergency medical profesional immediately or phone for an ambulance.
Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, abdomen and pelvis.
Types of infection associated with sepsis include:
In approximately one in five cases, the infection and source of sepsis cannot be detected.
Usually, your immune system will keep the infection limited to one place (known as a localised infection). Your body will produce white blood cells, which travel to the site of the infection to destroy the germs causing infection. A series of biological processes occur, such as tissue swelling, which helps fight the infection and prevents it spreading. This process is known as inflammation.
If your immune system is weakened or an infection is particularly severe, it can spread through the blood into other parts of the body. This causes the immune system to go into overdrive, and the process of inflammation affects the entire body.
This can cause more problems than the initial infection, as widespread inflammation damages tissue and interferes with the flow of blood, leading to a dangerous drop in blood pressure, which stops oxygen reaching your organs and tissue.
Everybody is potentially at risk of developing sepsis from minor infections, such as flu. However, some people are more vulnerable, including people who:
Sepsis is a particular risk for people already in hospital due to another serious illness. Despite the best efforts of doctors and nurses, secondary infections acquired in hospital are always a potential risk.
Hospital-acquired bacterial infections, such as MRSA, tend to be more serious as the bacteria causing the infection have often developed a resistance to antibiotics.
Sepsis is most often diagnosed by a blood test. Other tests may help determine the type of infection, where it is located and which body functions have been affected.
To diagnose sepsis, several tests may be carried out, including:
In the case of suspected sepsis, it is important to get a diagnosis as soon as possible so that appropriate treatment can be given. This can help stop the progress of sepsis and any long-term damage to the body.
Treatment of severe sepsis will vary for each patient depending on the initial infection, the organs affected and the extent of damage.
If your sepsis is detected early enough and has not affected organ or tissue function (uncomplicated sepsis), it may be possible to treat the condition at home. You will be prescribed a course of antibiotic tablets.
If the sepsis is severe, or you develop septic shock, you will need emergency hospital treatment, usually in an intensive care unit (ICU). ICUs are able to support any affected body function, such as breathing or blood circulation, while the medical staff focus on treating the infection.
Severe sepsis is treated with intravenous antibiotics (given directly into a vein). There will not usually be time to wait until a specific type of infection has been identified, so 'broad-spectrum' antibiotics will initially be given. Broad-spectrum antibiotics are designed to work against a wide range of known infectious bacteria, and can also treat some fungal infections.
Once a specific bacterium has been identified, a more 'focused' antibiotic can be used. This has the advantage of reducing the chance of the bacteria becoming resistant to antibiotics.
Intravenous antibiotics usually have to be given for 7 to 10 days.
If the sepsis is caused by a virus, antibiotics will not work. However, it is likely that antibiotics will be started anyway. This is because it would be too dangerous to delay antibiotic treatment until an accurate diagnosis is made. You will then need to wait until your body develops resistance to the effects of the virus. In some cases, antiviral medication may be given.
Source control means treating the source of the infection, such as an abscess or infected wound. This may require draining pus from infected tissue. In more serious cases, surgery may be required to remove the infected tissue and repair any damage.
Vasopressors are medicines used to treat low blood pressure. The two types of vasopressors used in the treatment of sepsis are dobutamine and noradrenaline.
They can help to increase blood pressure by stimulating the muscles involved in pumping blood around the body and constricting (narrowing) the blood vessels.
Vasopressors are normally given intravenously. Extra fluids may also be given intravenously to help increase blood pressure.
Depending on your condition and the effect sepsis has had on your body, you may also require:
Important: Our website provides useful information but is not a substitute for medical advice. You should always seek the advice of your doctor when making decisions about your health.